complications associated with Klinefelter's syndrome
Last reviewed 01/2018
- there is an increased risk of acquiring breast cancer in Klinefelter subjects,
with relative risk exceeding 200 times more than in a normal individual.
This may be due to high estradiol to testosterone ratio levels when compared
to karyotypically normal men or due to an increased peripheral conversion
of testosterone to estradiol
- endocrine complications includes:
- diabetes mellitus
- hypothyroidism
- hypoparathyrodism
- autoimmune disease conditions are more commoner, such as :
- SLE
- sjogren syndrome.
- rheumatoid arthritis
- venous stasis leading to varicose veins and leg ulcers
- decreased bone density - in almost 25% of patients with KS
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