NICE guidance - liraglutide

Last reviewed 01/2018

Summary points regarding the recommendation from NICE concerning the use of liraglutide are (1):

• 1) liraglutide 1.2 mg daily in triple therapy regimens (in combination with metformin and a sulphonylurea, or metformin and a thiazolidinedione) is recommended as an option for the treatment of people with type 2 diabetes,
  • when control of blood glucose remains or becomes inadequate (HbA1c >=7.5%, or other higher level agreed with the individual), and the person has:
    • a body mass index (BMI) >= 35 kg/m2 in those of European descent (with appropriate adjustment for other ethnic groups) and specific psychological or medical problems associated with high body weight, or
    • a BMI < 35 kg/m2, and therapy with insulin would have significant occupational implications or weight loss would benefit other significant obesity-related comorbidities
      
      
• 2) treatment with liraglutide 1.2 mg daily in a triple therapy regimen should only be continued if a beneficial metabolic response has been shown (defined as a reduction of at least 1 percentage point in HbA1c and a weight loss of at least 3% of initial body weight at 6 months)
  
  
• 3) liraglutide 1.2 mg daily in dual therapy regimens (in combination with metformin or a sulphonylurea) is recommended as an option for the treatment of people with type 2 diabetes, only if:
  • the person is intolerant of either metformin or a sulphonylurea, or treatment with metformin or a sulphonylurea is contraindicated, and
  • the person is intolerant of thiazolidinediones and dipeptidyl peptidase-4 (DPP-4) inhibitors, or treatment with thiazolidinediones and DPP-4 inhibitors is contraindicated~
    
    
• 4) treatment with liraglutide 1.2 mg daily in a dual therapy regimen should only be continued if a beneficial metabolic response has been shown (defined as a reduction of at least 1 percentage point in HbA1c at 6 months)
  
  
• 5) liraglutide 1.8 mg daily is not recommended for the treatment of people with type 2 diabetes
  
  
• 6) people with type 2 diabetes currently receiving liraglutide who do not meet the criteria specified in section 1 or 3, or who are receiving liraglutide 1.8 mg, should have the option to continue their current treatment until they and their clinicians consider it appropriate to stop

For full details then consult the NICE guidance (1).

Reference:

• 1) NICE (October 2010).Liraglutide for the treatment of type 2 diabetes mellitus