conditions and presentations when serological Coeliac disase screening should be considered

Last reviewed 01/2018

NICE suggest various presentations/conditions when serological testing should be considered but is not mandatory.

The list of conditions where coeliac disease serological screening should be considered includes:

• metabolic/endocrine disorders:
  • Addison's disease
  • amenorrhoea
  • metabolic bone disease (such as rickets or osteomalacia)
  • microscopic colitis
  • reduced bone mineral density
• autoimmune disorders:
  • autoimmune liver conditions
  • autoimmune myocarditis
  • Sjögren's syndrome
  • chronic thrombocytopenia purpura
• chromosomal disorders:
  • Down's syndrome
  • Turner syndrome
• presenting features that might prompt serological coeliac disease screening
  • low-trauma fracture
  • dental enamel defects
  • aphthous stomatitis (mouth ulcers)
  • persistent or unexplained constipation
  • persistently raised liver enzymes with unknown cause
  • polyneuropathy
  • recurrent miscarriage
  • depression or bipolar disorder
  • unexplained alopecia
  • unexplained subfertility
• other conditions;
  • epilepsy
  • lymphoma
  • sarcoidosis
  • microscopic colitis

Reference:

• 1. NICE (May 2009). Coeliac disease -Recognition and assessment of coeliac disease