diseases treated
Last reviewed 01/2018
Non-malignant disease:
- aplastic anaemia - results in disease free survival in more than 50% of patients
- thalassaemia
- sickle cell anaemia
- immunodeficiency diseases - including severe combined immunodeficiency disease, Wiskott-Aldrich syndrome
- Gaucher's disease
Malignant disease:
- acute myeloid leukaemia - high dose chemotherapy or radiotherapy and BMT is potentially curative; allogeneic is generally preferred
- acute lymphoblastic leukaemia - as standard intensive chemotherapy is so effective, BMT is reserved for special situations such as Philadelphia positive ALL. Allogeneic is usually preferred, as it is associated with a lower rate of relapse
- chronic myeloid leukaemia - with the introduction of imatinib, allogeneic stem cell transplantation is no longer considered as the first line treatment method in patients with chronic phase of CML (1)
- chronic lymphocytic leukaemia - allogeneic BMT preferred
- multiple myeloma - controversial as to whether allogeneic or autologous is the best; standard chemotherapy is rarely curative
Note that BMT is not considered part of standard therapy in the treatment of CLL or multiple myeloma.
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