connective tissue disease

Last reviewed 01/2018

Connective tissue disease may present with pyrexia of unknown origin. The long list of possible causes includes:

  • rheumatoid arthritis
  • systemic lupus erythematous
  • polyarteritis nodosa
  • temporal arteritis
  • Still's disease
  • Wegener's granulomatosis
  • "non-specific vasculitis"
  • acute rheumatic fever
  • polymyalgia rheumatica
  • polymyositis

These may cause a PUO which lasts for more than three weeks.