methotrexate
Last reviewed 08/2023
Methotrexate is an antifolate drug used in chemotherapy. Its action is to bind dihydrofolate reductase.
It is indicated for the treatment of various malignancies at high dose and for the treatment of psoriasis and rheumatoid arthritis as a titrated weekly dose (1).
The summary of product characteristics should be consulted before prescribing this drug.
Reference:
- (1) Current Problems in Pharmacovigilance (2000), 26, 10.
monitoring rheumatological disease
methotrexate in rheumatoid arthritis
methotrexate in therapeutic abortion
methotrexate in Crohn's disease and ulcerative colitis
N-terminal propeptide of procollagen type III (PIIINP) and methotrexate