paraneoplastic neuromyopathies
Last reviewed 01/2018
The most common tumours causing paraneoplastic neuromyopathies originate in the bronchus and the breast.
Paraneoplastic neuromyopathies include:
- peripheral neuropathies
- cortical cerebellar degeneration
- a polymyopathy resembling polymyositis
- a myasthenic syndrome
It is thought that an immune response to the tumour results in cross-reactive antibodies to nerve and muscle epitopes. A possible example of such an antibody is the "anti-YO" antibody which binds Purkinje cell cytoplasm and is associated with paraneoplastic cerebellar disease.
paraneoplastic cerebellar disease
Lambert Eaton myasthenia syndrome
Paraneoplastic neurologic syndromes associated with raised anti-Hu antibody levels