management
Last reviewed 01/2018
Immunosuppressive therapy should be commenced promptly after transplantation. The most popular regime is to prescribe cyclosporin A alone, or together with prednisolone and/or azathioprine i.e. mono, double or triple therapy.
Graft rejection should be monitored by:
- serum creatinine - a rise in levels during the first days or weeks after transplantation may be due to rejection or to other causes, for example, cyclosporin toxicity
- renal biopsy
Treatment of acute rejection consists of:
- high-dose intravenous steroids
- anti-thymocyte immunoglobulin
Mycophenolate mefetil may have a role in maintenance immunosuppression and in the treatment of acute rejection.
steroids (therapeutic information)