neonatal myasthenia
Last reviewed 07/2021
Neonatal myasthenia is a transient myasthenia gravis of the newborn. It occurs in 10-15% of myasthenic mothers. The infants suck and cry poorly, and are at risk from respiratory insufficiency.
The condition lasts less than one month. It is thought to be due to the passive transfer of anti-ACh receptor antibody from the mother.
Very rarely, these antibodies cause arthrogryposis multiplx congentia, ie multiple joint contractures and other deformities (1).
General care of the infant is required. Pharyngeal secretions, nasogastric feed and intubation should be removed, and anticholinesterase drugs administered.
Reference:
- (1) Prescribers' Journal (2000), 40 (2), 93-96.