AIRE trial
Last reviewed 03/2021
2006 patients with acute myocardial infarction, complicated at any time by left ventricular failure, were randomised to:
- ramipril, an ACE-inhibitor, 5 mg twice daily
- placebo
Randomisation took place 3-10 days post-MI (mean 5 days).
Treatment with ramipril resulted in:
- an absolute reduction in mortality of 6%
- an odds reduction for death of 26%
- the prevention of 45 premature deaths per 1000 patient years
Reference:
- Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. (1993). Lancet, 342, 821-8.