haemosiderosis
Last reviewed 10/2023
Haemosiderosis is a form of iron overload resulting in the accumulation of hemosiderin.
Haemosideosis can occur secondary to transfusions.
Idiopathic pulmonary hemosiderosis may occur.
Notes:
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Haemosiderin is an insoluble form of iron complexed with protein. It is one form of iron storage within tissue. It is visible microscopically with special stains.
- haemosiderin is an iron-storage complex. It is always found within cells
and appears to be a complex of ferritin, denatured ferritin and other
material
- iron within deposits of hemosiderin is very poorly available to supply iron when needed
- can be identified histologically with "Prussian-blue" stain.
- excessive accumulation of hemosiderin is usually detected within cells of the mononuclear phagocyte system or occasionally within epithelial cells of liver and kidney
- haemosiderin is an iron-storage complex. It is always found within cells
and appears to be a complex of ferritin, denatured ferritin and other
material
idiopathic pulmonary haemosiderosis