associated diseases
Last reviewed 07/2022
84% of patients with primary biliary cirrhosis have at least one other autoimmune disease.
These include:
- autoimmune thyroiditis
- Sjogren's syndrome
- CREST syndrome
- scleroderma
- rheumatoid arthritis
- fibrosing alveolitis
Rarer associations include:
- jejunal villous atrophy
- bullous pemphigoid
- capillaritis
- lichen planus
- IgM-associaed membranous glomerulonephritis
- renal tubular acidosis
- dermatomyositis
- polymyositis
- mixed connective tissue disease
- systemic lupus erythematosus
- Grave's disease
- ulcerative colitis
- autoimmune thrombocytopaenia
- breast cancer - there is a four fold increase in incidence in women with PBC
Note:
- natural history or clinical presentation of PBC is not modified by autoimmune comorbidities (1)
Reference:
dermatomyositis and polymyositis
mixed connective tissue disease
systemic lupus erythematosus (SLE)