inhibition of gastric acid secretion
Last reviewed 01/2018
The inhibition of gastric acid secretion may be achieved in two ways:
- H2 antagonists:
- ranitidine 150 mg bd or 300 mg nocte for 4-8 weeks
- ranitidine is preferred over cimetidine because it has fewer side effects and drug interactions
- both drugs are effective for the treatment of gastric and duodenal ulceration
- relapse of ulcer disease is common when therapy is discontinued
- proton pump inhibitors:
- the most commonly used example is omeprazole
- acts for 24 hr (longer than H2 inhibitors)
- are the first-line treatment for management of dyspepsia in primary care (1)
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