Xuebijing injection (XBJ) and sepsis (septicaemia)
Last edited 05/2023 and last reviewed 05/2023
Xuebijing injection (XBJ) and sepsis (septicaemia)
- an herbal-based intravenous preparation, was licensed in 2004 by the National Medical Products Administration (NMPA, China) for the treatment of sepsis and multiple organ dysfunction syndrome
- Xuebijing injection (XBJ)
- possesses an array of activities associated with its mechanism of protection in sepsis
- can exert an antagonistic effect on endotoxin
- an inhibitory effect on the uncontrolled release of endogenous inflammatory mediators produced by endotoxin-stimulated monocytes/macrophages
- can improve the coagulation disorders present in disseminated intravascular coagulation
- in this randomized clinical trial that included 1817 patients with sepsis, the 28-day mortality rate was 18.8% in the XBJ group vs 26.1% in the placebo group, a significant difference (1):
- among patients with sepsis, treatment with XBJ, compared with the placebo group, resulted in lower 28-day mortality
Reference:
- Liu S, Yao C, Xie J, et al. Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis: The EXIT-SEP Randomized Clinical Trial. JAMA Intern Med. Published online May 01, 2023. doi:10.1001/jamainternmed.2023.0780