switching antidepressant - SNRI (e.g. duloxetine or venlafaxine) to vortioxetine in adults
Last edited 04/2023 and last reviewed 04/2023
SNRIs to vortioxetine- is limited experience with this switch so extra caution is required to avoid serotonin syndrome.
- a direct switch, i.e. stopping one medicine and then starting the new medicine the following day, is normally possible.
- alternatively, gradually reduce the dose of the SNRI and stop; wait for a period before starting vortioxetine. Clinicians should decide the duration of the washout period on a case-by-case basis.
Reference:
- NHS Specialist Pharmacy Service (February 2023). SNRIs to other antidepressants: switching in adults