switching antidepressant (mirtazapine to vortioxetine) in adults
Last edited 03/2023 and last reviewed 03/2023
Mirtazapine to vortioxetine- limited experience with this switch so extra caution is required to avoid serotonin syndrome
- cross-tapering can usually be undertaken cautiously over 2 to 4 weeks, the speed is determined by individual tolerability
- alternatively, gradually reduce the dose of mirtazapine and stop; wait for a period before starting vortioxetine. Clinicians should decide the duration of the washout period on a case-by-case basis.
- NHS Specialist Pharmacy Service (February 2023).Mirtazapine to other antidepressants: switching in adults
summary advice - switching from mirtazapine to another antidepressant