switching antidepressant (tricyclic antidepressants (TCA) to moclobemide) in adults
Last edited 03/2023 and last reviewed 03/2023
Switching antidepressant (tricyclic antidepressants (TCA) to moclobemide)
Taper, washout and switch- for any TCA, you should gradually reduce the dose and stop. You will then need to wait for a period, dependent on the drug being switched from (see below), before starting moclobemide
- cross-tapering is not recommended due to the high risk of serotonin syndrome.
After stopping the TCA, wait 7 days before starting moclobemide.
From clomipramineAfter stopping clomipramine, wait 7 to 21 days before starting moclobemide. The manufacturer for clomipramine suggests a washout period of 21 days whereas other sources suggest shorter periods. Clinicians should decide the duration of the washout period on a case-by-case basis.
Reference:
- NHS Specialist Pharmacy Service (February 2023). Tricyclics to other antidepressants: switching in adults
summary advice - switching from tricyclic antidepressants (TCAs) to another antidepressant