alternative options for women taking continuous combined oral HRT preparation containing 2mg of oestradiol

Last edited 05/2022 and last reviewed 05/2022

Alternative options for women taking continuous combined oral HRT preparation containing 2mg of oestradiol

Women taking continuous combined oral HRT preparation containing 2mg of oestradiol, can consider the following:

• Elleste Duet (trade mark) Conti 2mg oestradiol + 1mg norethisterone
• Kliofem 2mg oestradiol + 1mg norethisterone acetate
• Indivina 2mg oestradiol + 5mg medroxyprogesterone acetate
• Or take oestrogen and progestogen separately:
  • Oral oestradiol 2mg plus either:
    • micronised progesterone: Utrogestan 100mg orally at night daily on continuous basis
    • Or Provera 5mg orally daily on continuous basis
    • Or Norethisterone 5mg orally daily on continuous basis (1mg would be sufficient for use in a continuous combined regimen but not available in stand-alone preparations)
      • Off license use of norethisterone in progestogen only contraceptive pills (e.g. Noriday 3 x tablets of 350 micrograms a day, will provide 1.05mg of norethisterone) may be considered as an equivalent alternative
    • Or Mirena IUS

Reference:

• British Menopause Society. HRT preparations and equivalent alternatives Information for GPs and other health professionals (Accessed 3/5/22)