alternative options for women taking sequential HRT preparations with transdermal oestradiol

Last edited 04/2022 and last reviewed 12/2022

Women taking sequential HRT preparations with transdermal oestradiol can consider the following options below:

• Evorel Sequi patches
  • provides transdermal oestradiol with sequential progestogen (norethisterone)
  • alternatively, women can consider transdermal oestrogen delivery with an alternative progestogen by taking oestrogen and progestogen separately:
    • Oestrogen:
      • Evorel 50 patches
      • Estradot 50 patches
      • Estraderm 50 patches
      • Femseven mono 50 patches
      • Progynova TS 50 patches
    • Or an oestradiol gel preparation such as Oestrogel or Sandrena:
      • Oestrogel one measure twice a day would be equivalent to the oestrogen dose in Evorel Sequi
      • Or Sandrena 1mg sachet a day would be equivalent to the oestrogen dose in Evorel Sequi
      • Or oestradiol spray Lenzetto three sprays (40 mcgm) would be equivalent to the oestrogen dose in Evorel Sequi
        
        
    • Progestogen:
      • Micronised Progesterone: Utrogestan 200mg orally for 12 days a month at night (cyclical)
      • Or Provera 10mg orally for 12 days a month
      • Or Norethisterone 5mg orally for 12 days a month
      • Or Mirena IUS

Reference:

• British Menopause Society. HRT preparations and equivalent alternatives Information for GPs and other health professionals (Accessed 27/4/22)