NASH and fibrosis progression
Last edited 02/2021 and last reviewed 09/2021
Fibrosis Progression in NASH
Approximately 40% of NASH patients progress to fibrosis globally (1,2)
- 5% and 10% of patients with NASH diagnosed
on their initial biopsy will present with clinically
significant fibrosis at this initial biopsy,
and an additional 15-20% will progress to
advanced fibrosis in less than a decade (2)
- age and presence of inflammation on initial biopsy are independent predictors of progression to advanced fibrosis (3)
Reference:
- Younossi Z, Koenig A, Abdelatif D, Fazel Y, Henry L,Wymer M. Global epidemiology of nonalcoholic fatty liver disease - meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology.2016;64(1):73-84
- Argo C, Northup P, Al-Osaimi A, Caldwell S. Systematic review of risk factors for fibrosis progressionin non-alcoholic steatohepatitis. J Hepatol. 2009;51(2):371-9.
- Hashimoto E, Tokushige K. Prevalence, gender,ethnic variations, and prognosis of NASH. J Gastroenterol. 2011;46(suppl 1):63–9.