prevalence of FH
Last edited 11/2018
Prevalence of FH
- Historically, the prevalence of heterozygous FH was 1 in 500 persons
- FH affects approximately between 1 in 250 to 1 in 500 people in the
UK, which is about 130,000 - 260,000 people, including children (1)
- ..Most cases of FH remain undiagnosed, and only an estimated
8-15% of cases are known (based on prevalence estimates of 1:250 and
1:500)
- ..Most cases of FH remain undiagnosed, and only an estimated
8-15% of cases are known (based on prevalence estimates of 1:250 and
1:500)
- in populations such as French Canadians, Ashkenazi Jews, Lebanese, and
several South African populations, the prevalence may be as high as 1
in 100 (2)
- most patients with homozygous FH have extreme hypercholesterolemia with
rapidly accelerated atherosclerosis when left untreated (1)
- heterozygotes arise when a mutation is inherited from one parent only; whereas homozygotes develop when the same mutated gene is inherited from both parents
- FH affects approximately between 1 in 250 to 1 in 500 people in the
UK, which is about 130,000 - 260,000 people, including children (1)
Reference:
- Public Health England (August 2018).Familial Hypercholesterolaemia Implementing a systems approach to detection and management.
- Raal FJ, Santos RD. Homozygous familial hypercholesterolemia: Current perspectives on diagnosis and treatment. Atherosclerosis. 2012;223:262-268.