differential diagnosis
Last reviewed 12/2021
This includes:
- other causes of leukoerythroblastosis:
- severe infection or inflammation - but teardrop poikilocytosis and giant abnormal platelets absent
- other causes of marrow fibrosis:
- metastatic carcinoma
- Hodgkin's disease
- hairy cell leukaemia - all distinguished on basis of tissue morphology
- other causes of massive splenomegaly:
- chronic malaria
- kala-azar
- Gaucher's disease (rare)
- other myeloproliferative disease:
- Philadelphia chromosome and low leucocyte alkaline phosphatase in CML
- raised haematocrit in polycythaemia vera
- markedly raised platelets with normal red cell morphology in essential thromobocytosis