clinical features
Last reviewed 01/2018
Acute features, noted from day 3 to day ten include:
- lethargy
- poor feeding
- hypotonia,
- opisthotonus
- convulsions
- high pitched cry, with or without fever
Intermediate features include:
- hypotonia
- developmental delay
Long term features, noted at 18 months, include:
- athetoid cerebral palsy
- high frequency hearing loss
- impaired vertical gaze
- mental retardation, which may be mild or absent
- dental dysplasia
hearing loss (sensorineural, acquired)
mental retardation (term that has been replaced by intellectual developmental disorder)