cellular effects
Last reviewed 01/2018
Interleukin-1 has the following effects:
- production of an antiviral state
- induction of T-lymphocyte proliferation by increasing:
- the amount of IL-2 produced by the T-lymphocyte
- the number of IL-2 receptors it has on its surface
- stimulation of B-lymphocytes
- chemotactic for lymphocytes
- stimulation of fibroblasts:
- synthesize collagen
- produce collagenase
- synthesize prostaglandins
- acts on the endothelium to increase leukocyte adhesion
- stimulate anorexia centrally
- increase beta-endorphin release and the number of receptors for endorphins; diminishes pain perception
- endogenous pyrogen, acting on anterior hypothalamus probably via action on prostaglandins
- restructuring of connective tissue:
- degradation of collagen and proteoglycan
- stimulation of osteoclasts
- stimulation of the acute phase response
- stimulates pituitary ACTH secretion