aetiology
Last reviewed 06/2023
Nephrogenic diabetes insipidus is most commonly due to osmotic diuresis. Familial disease causes profound polyuria but is uncommon; it is sex linked recessive and thus more severe in boys
Acquired causes include:
- osmotic:
- diabetes mellitus
- mannitol
- post obstructive uropathy
- chronic renal disease:
- interstitial nephritis
- polycystic kidneys
- sickle cell anaemia
- sarcoid
- amyloid
- metabolic:
- hypercalcaemia
- hypokalaemia
- drugs:
- lithium
- demeclocycline
- vitamin D
- methoxyfluorane
- solute washout from medulla due to prolonged polyuria of any cause