pathogenesis
Last reviewed 06/2023
There are probably multiple factors involved in the pathogenesis of fibromyalgia syndrome. However the sleep disturbance is thought to be of major importance:
- there is a loss of non-REM sleep
- a fibromyalgia-like syndrome may be induced in normal volunteers be depriving them of non-REM sleep
Reduced aerobic fitness may also be important.
Affective symptoms are associated with the fibromyalgia syndrome but whether they are primary or secondary is unknown.
A viral cause for the fibromyalgia syndrome is not supported by any evidence.