Murphy's sign

Last edited 02/2022 and last reviewed 02/2022

A positive Murphy's sign is seen in acute cholecystitis:

  • refers to where the patient stops breathing due to pain when an examiner touches the inflamed gallbladder
  • elicited by firmly placing a hand at the costal margin in the right upper abdominal quadrant and asking the patient to breathe deeply
  • if the gallbladder is inflamed, the patient will experience pain and catch their breath as the gallbladder descends and comes in contact with the palpating hand

A similar manoeuvre in the left upper quadrant should not elicit discomfort.