features of advanced disease
Last reviewed 01/2018
The criteria for advanced phase disease include:
- increasing splenomegaly despite full doses of cytotoxic therapy
- rapid white cell doubling
- white count that responds poorly to cytotoxic therapy
- anaemia or thrombocytopenia that responds poorly to cytotoxic therapy
- thrombocytosis >1000x10^9/l
- 10% blasts in the blood or marrow
- 20% (blasts + promyelocytes) in the blood or marrow
- acquisition of "non-random" chromosomal changes in addition to the Ph chromosome
- myelofibrosis
Reference:
- Goldman, J. (1997). ABC of clinical haematology. BMJ. 314, 657-660.