differential diagnosis
Last reviewed 01/2022
This includes:
- benign monoclonal gammopathy:
- there is no skeletal disease, no hypogammaglobinaemia, and no Bence Jones protein
- observe if in doubt since there is no advantage to early treatment of asymptomatic multiple myeloma
- smouldering (asymptomatic) multiple myeloma
- symptomatic multiple myeloma
- plasmacytoma (1)
- reactive polyclonal hypergammaglobulinaemia - distinguished on basis of single or polyclonal spike
- other malignant lymphoproliferative diseases:
- Waldenstrom's macroglobulinaemia
- lymphomas
- primary amyloidosis
- osteosclerotic myeloma
Reference:
monoclonal gammopathy of undetermined significance (MGUS)