2,3-diphosphoglycerate
Last reviewed 11/2023
2,3-diphosphoglycerate lowers the affinity of haemoglobin A for oxygen by binding to and stabilising deoxyhaemoglobin.
Hypoxia e.g. due to lung disease or high altitude, results in an adaptive rise in the concentrations of 2,3-DPG and an improvement in the quantity of oxygen delivered to the tissues.