clinical features
Last reviewed 01/2018
The presentation of Lambert Eaton syndrome:
- gradual onset of limb weakness - usually in the legs, less often in the arms (predominantly proximal pattern)
- patients usually describe fatigue on exercise - but characteristically, there is a post-tetanic increase in strength, lasting for a few seconds
- reflexes are usually absent or depressed but show post-tetanic potentiation
- ocular involvement - ptosis in 50% of cases; no other external ophthalmoplegia
- autonomic features - dry mouth, constipation, impotence