metastasis

Last reviewed 04/2023

Metastasis describes the state of having distant spread of a malignant tumour to a site removed from its origin. Generally, the aggressiveness and size of a given tumour is directly related to its ability to metastasize. An exception is CNS gliomas which are highly invasive but rarely metastasize.

Usually, the route of metastasis is characteristic of a particular tumour and can occur via:

  • direct extension from the site of origin
  • via fluid-filled spaces
  • through lymphatic spread
  • by traversing blood vessels and then haematogenous dissemination