Celecoxib versus diclofenac trial
Last reviewed 01/2018
The trial enrolled 655 patients with adult-onset rheumatoid arthritis and compared the anti-inflammatory efficacy and the gastrointestinal side-effects of celecoxib versus diclofenac.
The trial had a double-blind, double-dummy, randomised, parellel design.
Anti-inflammatory effects were assessed every four weeks for 24 weeks. 430 patients received an upper GI endoscopy to assess the presence of ulceration.
Reference:
- Emery, P. et al. (1999) "Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double-blind comparison". Lancet, 354, 2106-11.
COX-1 Vs COX-2 inhibitors (relative risk of GI side effects)