oxoglutarate dehydrogenase
Last reviewed 01/2018
Oxoglutarate dehydrogenase converts 2-oxoglutarate and coenzyme A into succinyl-CoA and carbon dioxide. NADH is generated from NAD.
The molecule of NADH is capable of generating 3 molecules of ATP via the electron transport chain.
Molecularly, it is a large enzyme complex which requires a number of co-factors:
- thiamine pyrophosphate
- coenzyme A
- FAD
- NAD
- lipoamide
A dietary deficiency of any of these reduces the efficacy of the enzyme; clinically, conditions like beri beri result.
Generally, the reaction is saturated and hence it is one of the targets for regulation of flux through the pathway.