switching antidepressant (vortioxetine to monoamine oxidase inhibitors (MAOIs)) in adults
Last edited 03/2023 and last reviewed 03/2023
Vortioxetine to monoamine oxidase inhibitors (MAOIs)
- switching to an MAOI is always a complex switch and you should follow specialist advice.
- gradually reduce the dose of vortioxetine and stop; wait 14 to 21 days before starting the MAOI
- the specialist will advise the duration of the washout period on a case-by-case basis taking into consideration the MAOI being started
- cross-tapering is not recommended due to the high risk of serotonin syndrome (1)
- is limited experience with this switch so extra caution is required to avoid serotonin syndrome (1)
Reference:
- NHS Specialist Pharmacy Service (February 2023). Vortioxetine to other antidepressants: switching in adults
summary advice - switching from vortioxetine to another antidepressant