suggested protocol for investigation of a raised GGT in an asymptomatic patient without risk factors for or clinical features of liver disease
Last reviewed 01/2018
Recommended investigation for isolated raised abnormal gamma glutamyl transpeptidase(GGT) in an asymptomatic patient without risk factors for or clinical features of liver disease in primary care (1):
- GGT has limited utility as a primary liver test
- the measurement of GGT is recommended in particular to establish the likely origin of a raised Alk Phos
- there is no clear consensus on
thresholds for further investigation (1)
- suggested that if a mildly raised GGT (<3 upper limit of normal (ULN)) then this is a justification for interval retesting
- if GGT rises >5 ULN justify consideration of ultrasound if cause is not apparent
Notes:
- in the absence
of clear guidance it is recommended that if results >2 ULN (unexplained by laboratory
tests)
- referral to secondary care is indicated (1)
Reference:
- Clinical Knowledge Summaries (accessed 6/4/07). How should I investigate an isolated 'slightly raised' gamma glutamyl transpeptidase in an asymptomatic adult? www.cks.library.nhs.uk