raised / high serum folic acid levels ( folate levels)

Last reviewed 06/2022

Raised serum folic acid level may occur in:

  • pernicious anaemia (or may be normal)
  • periods following folic acid administration or eating
  • vegetarians
  • blood transfusion
  • some cases of blind loop syndrome (secondary to folate synthesis by bacteria in the gut)
  • false elevation in haemolysed specimens (due to folate in red blood cells)
  • falsely increased to normal in some patients with severe iron deficiency (aetiology unknown)