aetiology
Last reviewed 01/2018
The majority of cases are idiopathic. However, there are a number of important associations including:
- trisomies 13 and 18
- Kallman's syndrome
- holoprosencephaly
- maternal drugs in pregnancy - in particular phenytoin
- Pierre-Robin sequence
- Goldenhar syndrome
- EEC syndrome
- there is an inherited element which is polygenic
Isolated cleft palate is commoner in females. However cleft palate associated with cleft lip is commoner in males.
disseminated intravascular coagulation
ondansetron in pregnancy - risk of oral clefts (cleft palate)