dipyridamole and breastfeeding

Last edited 07/2023 and last reviewed 07/2023

Dipyridamole and Breastfeeding

• Use with caution
  • is no published information on the amount of dipyridamole which passes into breast milk although levels are likely to be low.  It can be used with caution during breastfeeding but monitoring is required (1)
• monitoring
  • monitor the infant for diarrhoea, vomiting, skin reactions, irritability and for signs of bruising or bleeding (1)

Notes:

• is no published evidence of use of dipyridamole during breastfeeding although the manufacturers state that low levels were found in breast milk
• dipyridamole's pharmacokinetic properties are likely to limit the amount which passes into breast milk, and absorption by the infant (1)
• LactMed states (2):
  • until more data become available, dipyridamole should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant
  • if it is used by a nursing mother, monitor the infant for bruising and bleeding
• no side effects have been reported in breastfed infants.
• dipyridamole can be used therapeutically in infants from one month old (1)

Reference:

• NHS Specialist Pharmacy Service (July 2023). Using antiplatelet medicines during breastfeeding
• Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Dipyridamole. [Updated 2019 Jun 3]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK543169/