switching antidepressant (vortioxetine to serotonin and noradrenaline reuptake inhibitors (SNRIs) (e.g. duloxetine or venlafaxine)) in adults
Last edited 04/2023 and last reviewed 04/2023
Vortioxetine to serotonin and noradrenaline reuptake inhibitors (SNRIs)
- is limited experience with this switch so extra caution is required to avoid serotonin syndrome
- a direct switch, i.e. stopping one antidepressant and then starting the new antidepressant the following day, is normally possible
- alternatively, stop vortioxetine; wait for a period before starting the SNRI. Clinicians should decide the duration of the washout period on a case-by-case basis
Reference:
- NHS Specialist Pharmacy Service (February 2023). Vortioxetine to other antidepressants: switching in adults
summary advice - switching from vortioxetine to another antidepressant