World Health Organisation classification of acute myeloid leukaemia

Last reviewed 01/2018

WHO classification of AML includes:

• Acute myeloid leukemia with recurrent genetic abnormalities which includes
  • AML with a translocation between chromosomes 8 and 21 [t(8;21)]*
  • AML with a translocation or inversion in chromosome 16 [inv(16) or t(16;16;)]*
  • acute promyelocytic leukemia (APL) which usually has translocation between chromosomes 15 and 17*
  • AML with a translocation between chromosomes 9 and 11 [t(9;11)]
  • AML with a translocation between chromosomes 6 and 9 [t(6;9)]
  • AML with a translocation or inversion in chromosome 3 [inv(3) or t(3;3;)]
  • AML(megakaryoblastic) with a translocation between chromosomes 1 and 22 [t(1;22)]
  • Provisional entity: AML with mutated NPM1
  • Provisional entity: AML with mutated CEBPA
• Acute myeloid leukaemia with myelodysplasia-related changes
• Therapy-related myeloid neoplasms
• Acute myeloid leukaemia, not otherwise specified
  • AML with minimal differentiation
  • AML without maturation
  • AML with maturation
  • Acute myelomonocytic leukemia
  • Acute monoblastic/monocytic leukemia
  • Acute erythroid leukaemia
  • Pure erythroid leukaemia
  • Erythroleukemia, erythroid/myeloid
  • Acute megakaryoblastic leukemia
  • Acute basophilic leukemia
  • Acute panmyelosis with myelofibrosis

Reference:

• 1. Vardiman JW et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009;114(5):937-51