management
Last edited 05/2019
management
Treatment of NHL varies according to the the histologic type and stage of the disease.
- asymptomatic patients with indolent forms of advanced NHL may require frequent and careful observation in order to initiate treatment when the clinical course of the disease accelerates
- some patients may have a prolonged indolent while some may have more aggressive types of the disease which evolves rapidly and require immediate treatment
- radiation may be used for curative or palliative purposes and may be used alone or in combination with chemotherapy
Treatment can be divided into 2 broad categories:
- indolent NHL
- some examples of indolent NHL include - follicular lymphoma, lymphoplasmacytic lymphoma (Waldenström macroglobulinemia), marginal zone lymphoma, primary cutaneous anaplastic large cell lymphoma
- standard treatment options include
- local radiotherapy is the first-line treatment to people with localised stage IIA follicular lymphoma
- watchful waiting for asymptomatic patients
- Rituximab
- Rituximab with chemotherapy
- combination chemotherapy
- palliative radiation therapy
- aggressive NHL
- increasingly seen in human immunodeficiency virus (HIV)-positive patients;
- examples of aggressive NHL include - diffuse large B-cell lymphoma, Burkitt's lymphoma, mantle cell lymphoma, follicular lymphoma, peripheral T cell lymphoma
- standard treatment options include
- R-CHOP = Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone.
- other combination chemotherapy
- radiation therapy
- bone marrow or stem cell transplantation
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