interactions
Last reviewed 01/2018
- another DMARD - leflunomide should not be concomitantly administered with
another DMARD
- alcohol - this is because of the potential for additive hepatic side effects
- therefore alcohol should be avoided whilst on treatment with leflunomide
(1)
- the manufacturer advises caution when concomitantly prescribed with drugs
that are metabolised by the cytochrome P4502C (e.g. tolbutamide, warfarin,
phenytoin)
- a live vaccine should not be administered if a patient is currently, or has recently received, treatment with leflunomide
Check manufacturer's information for latest prescribing information.
Reference:
- 1) Drug and Therapeutics Bulletin (2000), 38 (7), 52-4.