hepatic inducing substances (of microsomal enzymes)
Last reviewed 01/2018
Drugs which induce hepatic enzymes may have the following effects:
- they may decrease the bioavailability of other drugs which are metabolised by those enzymes
- they may increase the bioavailability of drugs which require metabolism for their activation
Examples include:
- long term alcohol abuse
- rifampicin
- anticonvulsants, particularly phenytoin, carbamazepine, phenobarbitone and primidone
- spironolactone
- griseofulvin