clinical adverse events on penicillamine
Last reviewed 01/2018
- Rash
Often non-specific erythematous dry & itchy. Stop drug if severe. Stop drug if bullous reaction occurs. Consider using 1% hydrocortisone and/or antihistamines. Consider other causes. If mild re-introduce when settled.
- Mouth ulcers/Stomatitis
Stop if severe, reduce dose if mild/moderate. Consider carbenoxalone or difflam mouth washes. Consider other causes, check white cell count
- Loss of taste
Common early in treatment. Usually reappears with time or when drug stoppped.
- Metallic taste
Common early in treatment. Usually reappears with time or when drug stoppped. Stop if unacceptable.
- Nausea
Reduce dose and take with food. Stop if unacceptable.
- Lupus syndrome
Rare and difficult to diagnose. Stop drug and seek advice.
- Dyspnoea/Bronchiolitis
Stop drug and seek advice
- Myaesthenic symptoms
Stop drug and seek advice