epidemiology
Last edited 06/2019 and last reviewed 05/2022
- frequently seen in industrialized countries (in Europe and North America)
and is rare in underdeveloped countries (1)
- even in countries with several ethnic groups, the risk of developing the
disease was lower in those with a less westernised way of life (1)
- Crohn's & Colitis UK estimate there are at least 115,000 people in the UK
with Crohn's disease (3)
- annual incidence in the UK is approximately 5/100,000. A GP in UK can expect
a new case of Crohn’s disease every seven years (4)
- women more affected than men
- most commonly affected age group is between 15 and 30 years, although it may be seen in people of any age (4). There is also a second peak in the elderly.
- at the time of diagnosis
- 15% of people are older than 60 years
- 20-30% are younger than 20 years (4)
- familial clustering and involves ulcerative colitis as well as Crohn's disease
- more common in smokers than non-smokers (4:1)
- most common site of disease is the terminal ileum
Reference:
- (1) Malekzadeh F et al. Crohn's disease and early exposure to domestic refrigeration. PLoS One. 2009;4(1):e4288
- (2) Cummings JR, Keshav S, Travis SP. Medical management of Crohn's disease. BMJ. 2008;336(7652):1062-6
- (3) NICE (May 2019). Crohn's disease: management
- (4) National Institute for Health and Clinical Excellence (NICE) 2010. Infliximab (review) and adalimumab for the treatment of Crohn’s disease