Richter's syndrome
Last reviewed 01/2018
Richter's syndrome is an aggressive large cell lymphoma which results from the transformation of an isolated lymph node in chronic lymphocytic leukaemia. The remaining lymph nodes are unaffected.
- around 10% of patients with CLL develop Richter's syndrome with transformation into an aggressive lymphoma, Hodgkin's lymphoma or prolymphocytic leukaemia (PLL)
- polychemotherapies with antibodies are a treatment option (but without long-lasting remission)
- allogeneic stem cell transplantation can be used as an experimental option in physically fit patients (1)
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