other causes
Last reviewed 01/2018
Abnormal utilisation:
- drugs:
- anticonvulsants e.g. phenytoin and barbiturates
- barbiturates
- dihydrofolate reductase inhibitors e.g. methotrexate and trimethoprim
- very rarely, oral contraceptive pill
- enzyme deficiency states:
- methylenetetrahydrofolate reductase deficiency