clinical features
Last reviewed 01/2018
Patients tend to be between 50-70 years of age, with men and women equally affected.
Presentation is usually with jaundice, followed by pruritus; a sequence that is different from that in primary biliary cirrhosis.
Other common symptoms include:
- mild epigastric pain
- anorexia
- weight loss
- diarrhoea
Examination:
- hepatomegaly or palpable gallbladder - quite common
- splenomegaly and ascites - rare
Fever occurs late.