mode of action
Last reviewed 01/2018
The exact mechanism of cisapride's action is unknown. It is hypothesised that is works by an indirect cholinergic action e.g. by accentuating acetylcholine release within the myenteric plexus. It may also act via 5HT receptors, but not via dopaminergic activation.
Motility is increased throughout the bowel; stool frequency is increased in tandem.